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It also has a strong research base, with studies looking at how it interacts with cell signaling and the extracellular matrix (Pickart & Margolina, 2018)

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In acute tubular and glomerular injury models, it was found to be involved in the regulation of Ang receptors (ATR) and aminopeptidase A, thereby limiting renal damage by downregulating AT1R expression, inhibiting aminopeptidase A activity, and upregulating protective AT2R mRNA levels [54]