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investigated the effects of TMAO on glucose tolerance in high fat diet (HFD)-fed mice, they found that dietary TMAO exacerbates impaired glucose tolerance, blocks the insulin signaling pathway in the liver, and led to adipose tissue inflammation in mice ( Recently, a clinical study conducted by found that in obese patients, there is a positive correlation between TMAO levels and MAFLD histologic features

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Caspases act as common death effector proteins in various forms of cell death, being capable of cleaving aspartate residue positions in numerous proteins involved in cell proliferation and survival, as well as deoxyribonucleic acid (DNA) repair