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Columbianadin (CBN) has been shown to stabilize the palmitoylase ZDHHC5 through its interaction with TRIM7, which enhances the membrane localization and copper excretion function of the P2X7 receptor, ultimately leading to the inhibition of copper-induced cell death in M2 macrophages within the synovial membrane [219]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 97.Recober A, Kaiser EA, Kuburas A, Russo AF