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doi: 10.1038/s41386-020-0622-2 33 TakahashiKYanIKKogureTHagaHPatelT

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Metabolites that significantly correlated with PROMIS-Fatigue T -scores were overrepresented by the steroid hormone biosynthesis pathway (KEGG ID: M00107), including androgen and estrogen metabolism (SMPDB ID: SMP0000068) and androstenedione metabolism (SMPDB ID: SMP0030406) (Figure 4C), which included androsterone sulfate ( r = −0.26, p = 0.0009), epiandrosterone sulfate ( r = −0.25, p = 0.0016), etiocholanolone glucuronide ( r = −0.19, p = 0.018), and dehydroepiandrosterone sulfate (DHEA-S) ( r = −0.18, p = 0.023)