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Under conditions of oxidative stress, it localizes to the nucleus and binds to the promoter of peroxisome proliferator-activated receptor gamma-coactivator-1 alpha (PGC1α) gene leading to down-regulation of PGC1α-target genes and consequently disturbing mitochondrial morphology and function [265]

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In MPTP-induced PD mouse models, apoferritin downregulated the expression of DMT1 and ACSL4 while upregulating FSP1 expression, without affecting GPX4 levels, thereby preventing ferroptosis [78]