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In addition, in an exploratory analysis of a subset of the women studied with PET, we searched for possible cellular concomitants of the rCBF findings by examining the relationship between gene expression in the ESC/E(Z) gene complex (a set of 13 genes involved in epigenetic silencing by H3K27 methylation that is regulated by ovarian steroids and the expression of which differs in lymphoblastoid cell lines from women with PMDD and control women 17 ), and resting rCBF in specified brain regions (i.e., those differentially modulated by hormones and by a diagnosis of PMDD)

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