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Metabolic characteristics include: Half-life of approximately 184 hours (7.7 days) at the 2.4 mg dose Proteolytic degradation likely occurs through peptidase activity Sequential beta-oxidation of the fatty diacid side chain Metabolite elimination via renal and hepatic pathways The lipidation strategy with fatty diacids provides extended half-life through reversible albumin binding, similar to the mechanism employed by GLP1
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Marsh, ‘Medicines watchdog to investigate UK peptide clinics over health claims’, The Guardian, Apr
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